Correlation of TRIM29 expression in non-small cell lung cancer:a meta-analysis / 国际生物医学工程杂志

ABSTRACT

Objective To investigate the correlation between TRIM29 expression and non-small cell lung cancer (NSCLC) and its different histological types and clinicopathological features. Methods Using computer retrieves data databases such as PubMed, EMbase, China Knowledge Network and Wanfang Data, and collects relevant case-control studies at home and abroad. The time for searching the literature is as of August 1, 2018. Meta-analysis of the relationship between TRIM29 positive expression and clinicopathological features and tissue typing of non-small cell lung cancer was conducted by Review Manager 5.3 software. Results Five studies were included, including 1061 in the NSCLC group and 918 in the control group. Meta-analysis showed statistically significant differences between the expression of TRIM29 between NSCLC group and the control group [OR=18.32, 95％CI (4.62, 72.67), P<0.0001], squamous cell carcinoma and adenocarcinoma group [OR=37.05, 95％CI (2.45, 559.73), P=0.009], NSCLC lymph node metastasis group and NSCLC lymph node without metastasis group [OR=5.62, 95％CI (2.83, 11.17), P<0.00001], NSCLC (Ⅰ+Ⅱ) and (Ⅲ+Ⅳ) [OR=0.18, 95％CI (0.10, 0.32), P<0.00001] and NSCLC well differentiated group and the NSCLC middle and low differentiated group [OR=0.12, 95％CI (0.07, 0.21), P<0.00001], respectively. Conclusions The expression of TRIM29 is significantly correlated with NSCLC and its histological classification, lymph node metastasis, clinical stage and histological grade. This paper has certain help and reference value for the histological and clinical pathological features of NSCLC patients.