Regulating action of cyanidin-3-O-glucoside and cyanidin on osteoclast / 国际药学研究杂志

ABSTRACT

Cyanidin-3-O-glucoside is a kind of anthocyanin,which is one of the most abundant and widely available anthocya-nins in the world. The anthocyanidin part of it named cyanidin,without glucosidic group,is also widely available. A large number of epidemiological studies have shown that anthocyanins have the effect of preventing osteoporosis. Cyanidin-3-O-glucoside and its antho-cyanidin can inhibit the proliferation,differentiation and maturation of osteoclasts by NF-κβsignaling pathway,and inhibit the expres-sion of a variety of osteoclast markers,but its role in regulating NF-κβsignaling pathway and mechanism is not yet clear. This paper re-views the effects and mechanisms of cyanidin and cyanidin-3-O-glucoside on osteoclast,in hope of providing some research ideas for the prevention or treatment of osteoporosis.