Research progress of circulating tumor DNA detection in radiotherapy / 国际肿瘤学杂志

ABSTRACT

Circulating tumor DNA (ctDNA) refers to the DNA segment of the free tumor located in the peripheral circulation,which carries the biologic information derived from the tumor.In recent years,the innovation of the second generation sequencing technology has expanded the prospect of the clinical application of ctDNA analysis.Detection of ctDNA has made a great progress in the field of radiation therapy,especially in the aspect of evaluating the sensitivity of radiotherapy,ctDNA in peripheral blood is characterized by convenient extraction and high specificity.Detection of ctDNA is not only conducive to find minimal residual disease and metastasis,but also help clinicians better evaluate the curative effect and judge prognosis after radiotherapy,which will provide a new way of thinking for the diagnosis and treatment strategy of tumor.