Beta 2-microglobulin and tumors / 国际肿瘤学杂志

ABSTRACT

Beta 2-microglobulin (β2-MG) has low expression levels in tissues and cells of normal organisms,but its expression levels is increasing in tumor.The main function of β2-MG is to regulate signal transduction in tumor cells and promote tumor cell growth and angiogenesis.High level expression of β2-MG is associated with the occurrence,progression,metastasis and prognosis of human tumors and can serve as an independent indicator of tumor prognosis.It has been confirmed in a variety of tumor cells that agent targeting β2-MG is expected to become a new generation of targeted drugs.