Connecting Alzheimer's disease to diabetes:Underlying mechanisms and potential therapeutic targets / 基础医学与临床
Basic & Clinical Medicine
;
(12): 294-298, 2018.
Article
Dans Chinois
| WPRIM
| ID: wpr-693890
ABSTRACT
Alzheimer's disease(AD) is a risk factor for type 2 diabetes(T2D) and vice versa.A growing body of evidence indicates that these diseases are related both at epidemiological, clinical and molecular levels. Recent studies have begun to reveal common pathogenic mechanisms shared by AD and type 2 diabetes. Impaired neuronal insulin signaling and endoplasmic reticulum(ER) stress are found in animal models of AD,similar to observations in peripheral tissue in T2D. These findings shed light into mechanisms leading to brain dysfunction of AD in T2D patients. Here,we review the literatures on selected mechanisms shared between these diseases and discuss how the identification of such mechanisms may lead to novel therapeutic targets in AD.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Type d'étude:
Étude pronostique
/
Facteurs de risque
langue:
Chinois
Texte intégral:
Basic & Clinical Medicine
Année:
2018
Type:
Article
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS