A Study of Correlation between NDST3 Gene Polymorphism and Schizophrenia Among Han People in Yunnan / 昆明医科大学学报

ABSTRACT

Objective To investigate the association between rs11098403 of the NDST3 gene and schizophrenia among Han People in Yunnan. Methods A total of 364 Han patients with schizophrenia and 287 healthy Han people were enrolled in our study. SNaP shot was used to detect the genotype of rs11098403. Positive and Negative Symptoms scale (PANSS) was used to assess the symptoms of schizophrenia.Results No differences were found in the genotype and allele distributions of rs11098403 among patients and the control group (P＞0.05) . The allelic frequencies of rs11098403 showed no significant association with positive symptoms, negative symptoms or general symptoms (P＞0.05) . Conclusions Our study indicated that the association between NDST3 gene and schizophrenia might be specific to European population.