Research progress in laboratory detection of cytomegalovirus and its feasibility analysis for neonatal screening / 临床儿科杂志

ABSTRACT

Most of the human cytomegalovirus (HCMV) infection has no obvious clinical symptoms, but it can be latent for life and activated under specific conditions. HCMV active infection during pregnancy can lead to abortion, stillbirth, birth-defect and so on, which causes serious economic and social burdens. Both primary and secondary HCMV infection can lead to congenital infection of newborn, but there is still no effective method for the screening of HCMV secondary infection during pregnancy currently. Therefore, a comprehensive congenital HCMV screening for newborns is implemented for early intervention and thus reducing the consequences of congenital HCMV infection. In this paper, the methods of HCMV laboratory detection and its feasibility for neonatal screening are analyzed, in order to provide a basis for the selection of methods in neonatal congenital HCMV screening.