The molecular features of aggressive papillary thyroid microcarcinoma / 中华内分泌外科杂志

ABSTRACT

In recent years,the incidence of papillary thyroid microcarcinoma (PTMC) increased significantly and the mortality did not change obviously,resulting in the confusion and dilemma of clinical treatment.The majority of scholars believe that aggressive PTMC requires immediate surgical intervention,but there are no accurate clinical or pathologic features to predict or assess the aggressiveness of PTMC.In this review,the molecular genetic characteristics of aggressive PTMC are summarized from three aspectsgene mutation,microRNA and single gene expression.