Effects of fenvalerate exposure during puberty on oxidative stress in male rat testis / 上海交通大学学报（医学版）

ABSTRACT

Objective· To study the effects of fenvalerate exposure during puberty on oxidative stress in rat testis.Methods· Fifty male Sprague-Dawley (SD) rats were randomly divided into the control group (corn oil),low dose group (0.02 mg/kg fenvalerate),moderate dose group (1 mg/kg fenvalerate),high dose group (50 mg/kg fenvalerate) and intervention group (50 mg/kg fenvalerate+100 mg/kg N-acetyl-L-cysteine),ten rats for each group,for two months by gavage at four weeks of age.Malondialdehyde (MDA) content,activities of glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) in testis and testicular tissue morphology were detected.Results· Compared with the control group,the rat body weight and activities of GSH-Px and SOD in testis were significantly decreased in high dose group while MDA content was increased (all P＜0.05).Compared with the high dose group,MDA content was decreased and GSH-Px activity was increased in the intervention group (both P＜0.05).The results of testicular histology showed that with the increasing exposure dose,the spermatogenic cells were arranged loosely,the number of layers was decreased and the inner diameter of seminiferous tubules was increased.Conclusion· Exposure to fenvalerate during puberty may induce oxidative damage in testis tissue of male rats.