Role of phosphoglycerate mutase 1 in the occurence and development of tumor / 上海交通大学学报(医学版)
Journal of Shanghai Jiaotong University(Medical Science)
;
(12): 463-466, 2018.
Article
Dans Chinois
| WPRIM
| ID: wpr-695691
ABSTRACT
Phosphoglycerate mutase 1 (PGAM1) as one of the most important enzymes for glycolysis pathway,is highly expressed in multiple tumor tissues and negatively correlated with the prognosis of cancer patients.PGAM1 catalyzes the conversion of 3-phosphoglycerate (3-PG) to 2-phosphoglycerate (2-PG) in glycolysis pathway,then promoting anabolic pathways,energy generation,and maintaining redox balance during cancer cell proliferation and metastasis.The small molecule PGAM1 inhibitors have emerged as a promising strategy for anti-tumor therapy.In this review,the significance of PGAM1 in tumor was reviewed and the research progress of PGAM1 inhibitors was also introduced.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
langue:
Chinois
Texte intégral:
Journal of Shanghai Jiaotong University(Medical Science)
Année:
2018
Type:
Article
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS