The serum levels of IFN-γ and IL-10 in tuberculosis patients from East China before anti-tuberculosis treatment and the impact factors / 复旦学报（医学版）

ABSTRACT

Objective To describe the serum levels of Th1/Th2 cytokines of tuberculosis (TB) patients from East China before anti-TB treatment and the impact factors in order to provide information for TB diagnosis and treatment.Methods Four fields of TB appointed hospitals from two provinces in East China were selected.All newly diagnosed and registered active TB patients from Apr.,2013 to Mar.,2014 were investigated by self-designed questionnaire.ELISA was used to test the levels of IFN-γ and IL-10 in the serum.Results Totally 1 289 active TB patients were enrolled in the study sites,of whom 83.1 ％ and 75.5 ％ were reported having cough and sputum,respectively.The levels of IFN-γ and IL-10 were (2.086 ± 1.119) pg/mL and (2.576 ± 1.192) pg/mL,respectively.The ratio of Th1/Th2 was 0.81 (CIFN-γ/CIL-10,C stands for concentration).The level of IFN-γ was lower in patients with cough and sputum,while it was higher in those with fever,fatigue and night sweats (P＜0.05).In addition,the level of IFN-γ in initial treatment patients was higher than that in retreatment cases (P＜0.05).It was found that drinking tea could raise the level of IFN-γ (P＜0.05),drinking wine and taking a regular balanced diet could reduce the level of IL-10 (P＜0.05).Conclusions The symptoms of TB patients deserved attention.A healthy eating habits can help to achieve a high level of immunity and to correct the imbalance of Th1/Th2 cytokines in the course of disease.