Research progress of glycocalyx on endothelium in sepsis / 中华实用儿科临床杂志
Chinese Journal of Applied Clinical Pediatrics
; (24): 1435-1437, 2018.
Article
de Zh
| WPRIM
| ID: wpr-696613
Bibliothèque responsable:
WPRO
ABSTRACT
The mortality of sepsis remains high,and it is still a major cause of death in critically ill patients.But its pathophysiological mechanism remains a mystery,not yet fully clear.Endothelium play an important role in the development of sepsis.Maintaining the integrity of its surface glycocalyx to a certain extent reduces sepsis damage;and its destruction mediates a series of pathophysiological responses,including increasing vascular permeability by cell pathway or intracellular pathways,increasing the adhesion of white blood cells to endothelial cejls and a variety of cytokines to promote inflammatory response,activating of thrombin to coagulation dysfunction,promoting synthesis of nitric oxide to change vascular tension.The damage of glycocalyx as a first step in endothelial cell injury can be used as early diagnosis and prognosis of sepsis,which provides new ideas for the diagnosis and treatment of sepsis.
Texte intégral:
1
Indice:
WPRIM
Type d'étude:
Screening_studies
langue:
Zh
Texte intégral:
Chinese Journal of Applied Clinical Pediatrics
Année:
2018
Type:
Article