Research progress of PERK signaling pathway under endoplasmic reticulum stress in tumor / 实用肿瘤学杂志

ABSTRACT

During growth,invasion and metastasis,tumor cells undergo endoplasmic reticulum stress(ERS)under hypoxia,hy-poglycemia and other environmental stresses.In response to ERS,tumor cells induce unfolded protein response(UPR).PERK signa-ling pathway as a key pathway to activate UPR can promote survival,proliferation,invasion and protection of tumor cells by increasing tumor tolerance to adverse microenvironment,inducting angiogenesis,inducing autophagosome formation and activating apoptotic signal molecules.Tumor cells are induced apoptotic and autophagic death when UPR reaches a certain extent.