Clinicopathological Features of Low-Grade Thyroid-like Nasopharyngeal Papillary Adenocarcinoma / Journal of the Korean Cancer Association, 대한암학회지
Cancer Research and Treatment
;
: 213-218, 2017.
Article
Dans Anglais
| WPRIM
| ID: wpr-6979
ABSTRACT
PURPOSE:
Primary low-grade thyroid-like papillary adenocarcinomas are extremely rare neoplasms that generally originate in the nasopharynx. Here, we describe a novel case of a 15-year-old Chinese girl who was diagnosed with low-grade thyroid-like papillary adenocarcinoma, including a brief review of the literature to reveal the clinicopathological features of low-grade thyroid-like nasopharyngeal papillary adenocarcinoma. MATERIALS ANDMETHODS:
Immunohistochemistry was used to evaluate the expression of pan-cytokeratin (CKpan), cytokeratin (CK) 7, thyroid transcription factor 1 (TTF-1), vimentin, epithelial membrane antigen (EMA), thyroglobulin, CD15, S100, P40, CK20, CDX-2, glial fibrillary acidic protein (GFAP), and Ki-67. Additionally, in situ hybridization investigation was utilized to identify the presence of small Epstein-Barr virus (EBV)–encoded RNA.RESULTS:
Histopathological analysis revealed florid proliferation of papillary structures lined by columnar epithelial cells with fibrovascular cores. Immunohistochemically, the neoplastic cells were positive for CKpan, CK7, TTF-1, vimentin, and EMA, but negative for thyroglobulin, CD15, S100, P40, CK20, CDX-2, and GFAP. The Ki-67–labeling index reached 5% in the most concentrated spot. In situ hybridization for EBV was negative.CONCLUSION:
Due to the distinct rarity of low-grade thyroid-like papillary adenocarcinomaswith a favorable clinical outcome, a nationwide effort to raise public awareness of this neoplasm is required.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Thyroglobuline
/
Glande thyroide
/
Facteurs de transcription
/
Vimentine
/
ARN
/
Immunohistochimie
/
Adénocarcinome papillaire
/
Partie nasale du pharynx
/
Hybridation in situ
/
Herpèsvirus humain de type 4
Type d'étude:
Étude pronostique
Limites du sujet:
Adolescent
/
Femelle
/
Humains
langue:
Anglais
Texte intégral:
Cancer Research and Treatment
Année:
2017
Type:
Article
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