Research progress of Eph receptor family in the lung cancer and its potential application as targets of lung cancer / 实用肿瘤学杂志

ABSTRACT

The Eph receptors and their ligand Ephrins are closely associated with angiogenesis,cell migration,neuronal local-ization and embryonic development.More and more studies have shown that the Eph receptor and Ephrins are involved in the occur-rence and development of various cancers.In this article,we will focus on the Eph receptor family involved in the formation and devel-opment of lung cancer and metastasis,drug resistance and other mechanisms as well as their potential as targeted therapy of lung canc-er.