Effectiveness Evaluation Analysis on Berberine Tablets Combination with Metformin Treating Type 2 Diabetes / 现代医院

ABSTRACT

Objective To explore the clinical effect of Berberine tablets combination with Metformin treating type 2 diabetes (T2DM). Methods Of 80 cases of T2DM were randomly divided into control group and treatment group, 40 cases each group. The control group was given the treatment of Metformin, and the treatment group was given an additional treatment of Berberine tablets. After 3 months treatment, the indexes of blood sugar levels, HOMA-β, HOMA-IR and inflammatory factor were compared between the two groups. Results After treatment, the levels of FPG, 2hPG and HbA1c in the treatment group were all obviously lower than the control group (P＜0. 05). The indexes of HOMA-β and HOMA-IR in the treatment group were lower than the control group (P＜0. 05). And the levels of CRP, IL-6 and TNF-α in the treatment group were all lower than the control group (P＜0. 05). Conclusion The treatment of Berberine tablets combination with Metformin could alleviate inflammatory response, promote secretion of insulin βcell, increase cell insulin sensitivity and achieve a variety of hypoglycemic effect.