Impact of interleukin-6 on long-term prognosis in patients undergoing coronary drug-eluting stent im-plantation / 心血管康复医学杂志

ABSTRACT

Objective:To explore impact of serum level of interleukin(IL)-6 on long-term prognosis in patients un-dergoing intracoronary drug-eluting stent(DES)implantation.Methods:A total of 2017 patients,received success-ful DES implantation in our hospital from Feb 2010 to Feb 2013 were selected.According to IL-6 level change be-tween before and after surgery,they were divided into elevated IL-6 group(n=994)and decreased IL-6 group(n=1023),and both groups received postoperative follow-up of one,two and three years.Results:Compared with de-creased IL-6 group after one-year follow-up,there were significant rise in levels of high sensitive C reactive protein [(22.3 ± 6.0)ng/ml vs.(30.8 ± 7.0)ng/ml],low density lipoprotein cholesterol[(2.5 ± 0.9)mmol/L vs.(2.6 ± 1.0)mmol/L]and serum creatinine[(77.9 ± 34.9)μmol/L vs.(88.8 ± 35.6)μmol/L],and significant reduction in level of high density lipoprotein cholesterol[(1.1 ± 0.4)mmol/L vs.(1.0 ± 0.3)mmol/L]in elevated IL-6 group,P=0.001 all;compared with decreased IL-6 group after two-year follow-up,there were significant rise in target lesion revascularization rate(1.6% vs.3.1%)in elevated IL-6 group(P=0.021);compared with decreased IL-6 group after three-year follow-up,there were significant rise in target lesion revascularization rate(1.3% vs. 3.8%),cumulative incidence rate of MACE(9.8% vs.15.6%),accumulative mortality(1.6% vs.3.3%) and cardiogenic mortality(0 vs.1.1%)in elevated IL-6 group(P = 0.001). Conclusion:Compared with decreased IL-6 group,after coronary drug-eluting stent implantation,long-term prognosis of elevated IL-6 group is significantly poor.