Correlation between NT-proBNP and plasma interleukin-15 level in patients with chronic congestive heart failure / 心血管康复医学杂志

ABSTRACT

Objective:To explore change of plasma interleukin 15 (IL-15) level and its correlation with N terminal pro B-type natriuretic peptide (NT-proBNP).Methods:A total of 205 patients diagnosed as CHF were sequentially en-rolled as CHF group ,and another 52 healthy adults undergoing physical examination simultaneously were regarded as healthy control group .According to NYHA cardiac function class ,CHF group was further divided into class II group (n＝55) ,class III group (n＝87) and class IV group (n＝63).Plasma IL-15 level was measured and compared among all groups ,and correlation among plasma level of NT-proBNP ,left ventricular ejection fraction (LVEF) and plasma IL-15 level were analyzed in CHF patients .Results: Compared with healthy control group ,there was signif-icant rise in plasma NT-proBNP level [ (71 ± 33) pg/ml vs.(5884 ± 1379) pg/ml] ,and significant reduction in LVEF [(57 ± 7)% vs.(31 ± 8)% ] in CHF group ,P＝0.001 both .Plasma IL-15 level of CHF group was significant-ly higher than that of healthy control group [(18.35 ± 6.42) ng/L vs.(7.78 ± 3.11) ng/L] , P＝0.001 ;compared with class II group ,there was significant rise in plasma IL-15 level [ (10.24 ± 3.61) ng/L vs.(20.17 ± 6.35) ng/L vs.(21.94 ± 7.32) ng/L] in class III and IV group , P＝0.001 both ,and there was no significant difference be-tween class III and class IV group (P＝0.187).Pearson correlation analysis indicated that plasma IL-15 level was significant positively correlated with plasma NT-proBNP level ( r＝ 0.172 , P＝ 0.038).Conclusion:Plasma IL-15 level of CHF patients is significantly higher than that of healthy subjects ,and significant positively correlated with NT-proBNP level ,and it has certain relationship with heart failure severity ,so it may become a new marker for pre-dicting CHF .