Effect of 0.1％ and 0.3％ sodium hyaluronic ophthalmic solution on tear film stability and visual quality in FS-LASIK dry eye / 中华实验眼科杂志

ABSTRACT

Objective This study was to study the effect of 0.1％ and 0.3％ sodium hyaluronic ophthalmic solution on tear film stability and visual quality of dry eye patients after femtosecond laser-assisted laser in situ keratomileusis (FS-LASIK).Methods A prospective randomly controlled study was designed.Pre-surgery normal patients were evaluated again at 1 week after FS-LASIK,60 mild and severe dry eye patients were enrolled from April 2016 to April 2017 in Tianjin Medical University Eye Hospital.Then 0.1％ and 0.3％ sodium hyaluronate were randomly given in each dry eye group.Ocular surface disease index (OSDI),optical quality analysis system Ⅱ(OQAS Ⅱ),Keratography 5M and corneal staining were performed before operation,1 week (before instillation and 15,30,60,120 and 180 minutes after instillation),1 month and 3 months after operation.This study was approved by the Ethic Committee of Tianjin Medical University Eye Hospital (2015KY-04).Informed consent was obtained from all subjects after explanation of the nature and possible consequence of the study.Results The 0.3％ sodium hyaluronate group was better than 0.1％ sodium hyaluronate group in alleviating OSDI score and cornea staining at 3 months in the mild dry eye group (Fgroup =10.913,P =0.003;P =0.027).Compared with the before operation,the objective scatter index(OSI) was increased at 1 week before instillation and many different time points after instillation in both 0.1％ sodium hyaluronate group and 0.3％ sodium hyaluronate group,with significant differences between them (all at P＜0.05),there was no statistically significant difference in OSI at 1 month and 3 months after surgery compared with before surgery in both 0.1％ and 0.3％ sodium hyaluronatc group.In 0.1％ sodium hyaluronic group and 0.3％ sodium hyaluronic group,the mean value of total OSI at 1 week after surgery were siginifcantly higher than that before surgery (P=0.046,0.060).In 0.1％ sodium hyaluronate group,the mean values of total OSI at various time points after instillation were not statistically different from that before surgery (all at P＞0.05),total OSI at 1 month and 3 months after operation were higher than that before surgery (P =0.047,0.017);In 0.3％ sodium hyaluronic group,the mean value of total OSI at 15,30,60 and 120 minutes after instillation were significantly higher than that before surgery (all at P＜0.05),and compared with the total OSI before surgery,no statistical differences were found at 1 month and 3 months after operation (P =0.046,0.667).Significant differences were found in NIBUT avg among different time points in the mild dry eye patients (Ftime =2.290,P =0.022).In 0.1％ sodium hyaluronic group and 0.3％ sodium hyaluronic group,the NIBUT avg at 1 week after surgery were significantly lower than that before operation (both at P＜0.05).Compared with the before operation,no significant differences were found at the following 3 hours after instillation in 0.1％ sodium hyaluronic group (all at P＞0.05).In 0.3％ sodium hyaluronic group,the NIBUT avg at 60,120 and 180 minutes after instillation were significantly lower than that before surgery (P=0.040,0.047,0.041),and NIBUT avg at 3 months after operation was significantly lower than that before surgery (P =0.044).Conclusions The 0.3％ sodium hyaluronic is better than 0.1％ sodium hyaluronic in alleviating the OSDI score and cornea staining on the mild dry eye post FS-LASIK,and the tear film stability and related visual quality fluctuated over time after the application of 0.3％ sodium hyaluronic.