Reaearch of the association of epicardial fat volume indexed to body surface area with the risk of coronary heart disease and vascular remodeling / 医学研究生学报

ABSTRACT

Objective Epicardial fat volume(EFV)is the risk factor of coronary heart disease(CHD)and positive remod-el of coronary artery.This study aimed to investigate the association of the unit surface area Epicardial fat volume(Epicardial fat volume indexed to the body surface area,EFVi)with the risk of coronary heart disease(CHD)and vascular remodeling. Methods A total of 208 consecutive patients with suspected CHD underwent coronary computed tomography angiography(CTA)were selected between December 2016 and December 2017 in cardiology department, Nanjing General Hospital of Nanjing Military Area Command. They were divided into CHD group(n=135)and non-CHD group(n=73). 135 CHD group patients were divided into 2 subgroups according to the type of vascular Remodeling-positive remodeling group[vascu-lar remodeling index(RI)>1.05,n=56]and non-positive remode-ling group[vascular remodeling index(RI)<1.05,n=79]. Clinical data was collected and peripheral blood lipid was detected in the same period;EFV and RI were determined by coronary CTA and software on a workstation[Syngo MMWP(VE32B)];.EFVi was calculated and the association with plate property and vascular remodelingwas explored;To investigate the risk factor of vascular remodeling Results The EFVi and EFV[(128.91±52.22)cm3,(74.12±28.77) cm3/m3]of CHD group were obviously higher than that of non-CHD group[(76.14±30.40)cm3,(45.41±16.97)cm3/m3](P<0.01). Logistic regression analysis showed that EFVi(OR=1.06,95% CI:1.02-1.10),LDL-C(OR=2.56,95% CI:1.06-6.12),EFV (OR=1.05,95% CI:1.02-1.07)were the risk factors of CHD.Compared with the positive remodeling group[(128.91±52.22)cm3, (74.12±28.77)cm3/m3]of CHD group were obviously higher than that of non-CHD group[(17.25±6.43),(38.15±10.56)μm3], the fiber volume[(23.66±9.05)μm3]and calcification volume[(182.75±46.51)μm3]were significantly higher in non-positive re-modeling group. While EFVi[(68.31±25.16)cm3/m3]was significantly lower than the positive remodeling group[(92.15±31.04) cm3/m3](P<0.05). Hypertension(OR=2.78,95% CI:1.12-6.88),TG(OR=1.96,95% CI:1.04-3.70),LDL-C(OR=3.91, 95% CI:2.58-7.51)and EFVi(OR=1.02,95% CI:1.01-1.31)were high risk factors of vascular remodeling(P<0.05). Conclusion EFVi can be used as an important predictor of coronary heart disease risk and coronary vascular positive remodeling.