The current progress in the mechanism of insulin malfunction in central nervous system leading to the spo-radic type of Alzheimer's disease and its applications / 医学研究生学报

ABSTRACT

Alzheimer's disease is the most common disease which causes dementia in senior citizens. It is a neurodegenerative disease which is characterized by the degradation of the neurons and synapses in the brain. Usually,the irreversible and progressive neuron loss particular in the regions of cortex and hippocampus,the plaques of the accumulation of amyloidosis outside the cells,as well as the neurofibrillary tangles which is made by the hyperphosphorylation of Tau microtubule proteins can be seen in the lesion loca-tion of the patients. The Insulin malfunction in the central nervous system is now regarded as an important pathogenesis of Alzheimer's disease. This review focuses on the development of the knowledge of the mechanism of the malfunction of insulin in the central nervous system leading to the sporadic type of Alzheimer's disease and its applications,aiming to provide a reference in the study of Alzheimer 's disease.