Meta Analysis of the Relationship between Overweight, Obesity and Acute Mountain Sickness / 医学研究杂志

ABSTRACT

Objective To investigate the relationship between overweight,obesity and acute mountain sickness(AMS).Methods We searched the WanFang,CNKI,VIP,PubMed,Embase,Springer,Google Scholar,Cochrane databases.AMS,acute high altitude disease,acute high altitude disease (AHAD),hypoxic ventilatory response (HVR),obese,obesity,BMI,Body Mass Index,cohort study,case-control study,cross-sectional study and observational study were used to search literatures which studied association between overweight,obesity and AMS during 2007-2016.Literatures were then evaluated by two evaluators.RevMan 5.3 software was utilized for statistical analysis.Results Six articles with 6323 cases were included in the study.The heterogeneity test result revealed that included studies were statistically heterogeneous (I2 =93％,P ＜ 0.01),therefore,the random effect model was used to analyze.Obesity and overweight significantly increased the occurrence of AMS with an OR of 2.39 (95％ CI:1.21-4.70).Egger's test indicated that there was no publication bias (P ＞ 0.05).Conclusion Overweight and obesity can be used as predictors of occurrence for AMS.