Clinical Value of Serum ANCA, ACLA and β2-MG in Diagnosis of Early Diabetic Nephropathy / 医学研究杂志

ABSTRACT

Objective To explore the clinical value of serum ANCA (antineutrophil cytoplasmic antibody),and ACLA (anticardiolipin antibodies) combined with β2-MG (β2 microglobulin) in the diagnostis of DN (early diabetic nephropathy).Methods Fifty cases of patients with early diabetic nephropathy treated in our hospital from February 2016 to February 2017 were selected,and 50 normal volunteers were collected,as the observation group and control group.Positive rates of ANCA,ACLA and β2-MG expression of the patients were observed and recorded.The correlation of ANCA,ACLA,β2-MG and DN was explored and analyzed,and ANCA,ACLA,β2-MG and ANCA,ACLA combined with β2-MG diagnostic efficiency were evaluated.Results The positive rates of ACLA,ANCA,and β2-MG antibodies in the observation group were significantly higher than those in the control group (P ＜ 0.05).There was difference in DN incidence in different levels of ANCA,ACLA,β2-MG (P ＜0.05).There was a significant correlation in ACLA,ANCA,β2-MG and myocardial infarction.Combined diagnostic sensitivity ACLA + ANCA + β2-MG was significantly higher than that of pure ACLA,ANCA,β2-MG (P ＜ 0.05).The specificity was lower than that of simple RBP,Hcy and ultrasonic scoring diagnosis.The consistency was higher than that of pure ACLA,ANCA,and β2-MG (P ＜ 0.05).According to the results of ROC curve,the diagnostic efficiency of ACLA + ANCA + β2-MG combined with early diagnosis of DN was significantly better than that of pure ACLA,ANCA and β2-MG.Conclusion Combined use of ACLA + ANCA + and β2-MG can improve diagnostic accuracy of early diabetic nephropathy,which is more effectively than pure ACLA,ANCA,and β2-MG for diagnosis,and it is worthy of clinical promotion.