Study on the Relationship between Ischemia Modified Albumin and the Degree of Myocardial Injury and Prognosis of Neonates with Pneumonia Combined with Heart Failure / 医学研究杂志

ABSTRACT

Objective To explore the clinical significance of ischemia modified albumin for the degree of myocardial damage and prognosis of neonates with pneumonia combined with heart failure.Methods Select 60 samples of neonates with pneumonia,neonates with pneumonia combined with heart failure,and normal neonates respectively,then detect and compare the level of ischemia modified protein (IMA),cTnI and CK-MB from the three groups neonates' serum.Calculate the left ventricular Tei index of three groups neonates by ultrasonic testing and compare.Compare the positive rates of IMA,cTnI,and CK-MB in neonates with pneumonia combined with heart failure group.Analyze the correlation between IMA and cTnI,CK-MB,and left ventricular Tei index in neonates with pneumonia combined with heart failure group.The incidence of death and cardiac events were recorded by follow-up visiting neonates with pneumonia combined with heart failure,and the relationship between IMA level and prognosis was analyzed.Results The differences in three indexes of IMA,cTnI and CK-MB were statistically significant in the three groups,all of which were significantly higher in neonates with pneumonia combined with heart failure group than those in other two groups (P ＜ 0.05).The positive rate of IMA in neonates with pneumonia combined with heart failure group was the highest 88.33％ (P ＜ 0.05).The left ventricular Tei index of the pneumonia combined with heart failure neonates group was 0.42 ± 0.11,which was significantly higher than the other two groups (P ＜ 0.05).The IMA and cTnI,CK-MB and left ventricular Tei index in pneumonia combined with heart failure neonates were all positively correlated (r =0.81,r =0.73,r =0.69,P ＜ 0.05).Both the mortality and cardiac events in the high IMA group were significantly higher than that in the mid-level IMA group and the low-level IMA group (P ＜ 0.05).Conclusion The ischemic modified albumin can be used as an effective indicator for the degree of myocardial damage and prognosis of neonates with pneumonia combined with heart failure.