Study on the relationship between the level of serum albumin (ALB) and fibrinogen (FIB) in patients with cerebral infarction / 中国基层医药

ABSTRACT

Objective To study and explore the relationship between neural function defect and plasma albumin (ALB) and fibrinogen (FIB) level in young patients with cerebral infarction .Methods 83 young patients with cere-bral infarction were selected as the observation group ,62 healthy people were randomly selected as the control group . The serum albumin,fibrinogen and neurological deficit scores were compared between the two groups .According to the degree of nervous function defect ,the patients of the observation group were divided into mild group ,moderate group and severe group,the plasma albumin in patients with different neurologic impairment and the level of fibrinogen were compared.Results Compared to the control group, the plasma albumin [(51.64 ±13.91 ) g/L], fibrinogen [(6.59 ±2.93)g/L] and neurological deficit scores [(22.95 ±14.32)points] in the observation group were signifi-cantly higher (t =8.132,10.764,10.888,all P <0.05).In the observation group,the plasma albumin and fibrinogen levels had statistically significant differences in patients with different degree of neural function defect (F =9.959, 7.192,all P <0.05),and plasma albumin,fibrinogen were positively correlated with neurological deficits (r =0.635, 0.726,all P <0.05).Conclusion The serum albumin and fibrinogen levels in young patients with cerebral infarc-tion are abnormally increased,their expression levels are closely related with neural function defect degree ,and can be used as important indicators of disease monitoring ,assessment of prognosis.