Association between serum Fractalkine and obesity and type 2 diabetic mellitus / 中国糖尿病杂志

ABSTRACT

Objective To investigate the association between serum chemotactic factor fractalkine (FKN) level and obesity and type 2 diabetic mellitus (T2DM).Methods According to BMI,88 cases of healthy persons with normal glucose tolerance (NGT) were divided into normal weight group (A group,n =44,BMI＜ 24 kg/m2) and obesity group (B group,n =44,BMI≥ 24 kg/m2);88 cases of newly diagnosed T2DM patients (T2DM group) were divided into the normal weight group (C group,n=44,BMI＜24 kg/m2) and obesity group (D group,n=44,BMI≥24 kg/m2).FKN and TNF-α levels were measured by ELISA.Results Serum FKN in T2DM group (0.625± 0.090) ng/ml was higher than that in NGT group (0.395±0.110) ng/ml (P＜0.01).The levels of FKN in C group (0.55±0.08) ng/ml were higher than that of A group (0.34±0.14) ng/ml and B group (0.45±0.08) ng/ml P＜0.01).Serum FKN was positively correlated with and the levels of FPG,HbA1 c,WHR,BMI,C reactive protein (C-RP),HOMA-IR and TNF-α (r=0.578,0.592,0.616,0.596,0.909,0.872 and 0.827,P＜0.01) in T2DM group.FKN was negatively correlated with HDL-C (r =-0.216,P ＜ 0.05).Multivariate regression analysis showed that C-RP,BMI and TNF-α were independent factors related to FKN (β=0.441,0.158 and 0.221,P＜0.05).Conclusion Serum FKN is closely related to inflammation response in T2DM patients.FKN may play an important role in the pathogenesis and development of T2DM and obesity.