Research progress in high-mobility group box-1 and diabetic peripheral neuropathy / 中国糖尿病杂志

ABSTRACT

A chronic low-grade inflammation plays an important role in the development and progression of diabetic peripheral neuropathy (DPN).High-mobility group box-1 (HMGB1) is an evolutionarily conserved non-histone chromatin-binding protein.Nuclear HMGB1 can be released into the extracellular space when disease appears.Extracellular HMGB1 acts as a pro-inflammatory cytokine implicated in the pathophysiology of neuronal tissue inflammation.Therefore,investigating the role of HMGB1 in the development of DPN and exploring new therapeutic strategies may be helpful in the prevention and treatment of DPN.