Correlation between cognitive function and homocysteinemia in patients with depression after cere-bral infarction / 中华行为医学与脑科学杂志

ABSTRACT

Objective To explore the cognitive function and the level of serum homocysteine(Hcy) in patients with depression after cerebral infarction,and to analyze their correlation. Methods Fifty-two pa-tients with cerebral infarction and 50 patients with depression after cerebral infarction were selected.The cog-nitive function of patients was evaluated by Montreal cognitive assessment( MoCA) score and event-related potentials P300.Hcy concentration was detected by enzyme-linked immunosorbent assay(ELISA),and the correlation between the cognitive function and the Hcy concentration was analyzed. Results Compared with the patients without depression after cerebral infarction(MoCA(25.02±6.12),latency of P300(317.00± 28.87)ms,amplitued of P300(7.80±3.10)μV),the MoCA score of the patients with depression after cere-bral infarction significantly decreased(20.92±6.23),the latency of P300((370.84±40.62)s) significantly prolonged and the amplitude of P300((5.70±2.13)μV) significantly decreased(all P＜0.05).Compared with patients without depression after cerebral infarction(9/52,17.3%),the percent of serum hyper-Hcy in the patients with depression after cerebral infarction(24/50,48.0%) increased,and the difference was statisti- cally significant (χ2＝10.972,P＜0.01).The level of Hcy in the patients with depression after cerebral infarc-tion was negatively correlated with the score of MoCA ( r＝－0.675,P＜0.05) and the latency of P300 ( r＝0.813,P＜0.05),but negatively correlated with the amplitude of P300 (r＝－0.725,P＜0.05). Conclusion -Patients with depression after cerebral infarction have different degrees of cognitive impairment,and increased Hcy may be one of the factors that cause cognitive impairment in patients with depression after cerebral in-farction.