Pien Tze Huang Inhibits the Biological Behavior of Tongue Squamous Carcinoma Tca8113 Cells / 中国医科大学学报

ABSTRACT

Objective To investigate the effects of Pien Tze Huang on the biological behavior of tongue squamous carcinoma Tca8113 cells and its molecular mechanism.Methods Tca8113 cells were incubated with Pien Tze Huang at different doses.The proliferation of Tca8113 cells was examined by MTT assay.The distribution of the cell cycle was evaluated by PI staining.The expression of the p-STAT3 and Bcl-2 proteins was assessed by Western blotting.Results MTT assay showed that Pien Tze Huang inhibited the proliferation of Tca8113 cells in a dose-dependent manner.PI staining showed that Pien Tze Huang arrested cells in the G0/G1 phase.The results of Western blotting suggested that Pien Tze Huang inhibited STAT3 protein phosphorylation and Bcl-2 protein expression.Conclusion Pien Tze Huang inhibits the proliferation of tongue squamous carcinoma cells.