Mechanisms of PPARα,sterol regulatory element binding proteins and AMP-activated protein kinase in alcoholic fatty liver diseases:review / 中国药理学与毒理学杂志

ABSTRACT

Alcoholic fatty liver disease (AFLD) is the first step to wards alcoholic liver disease (ALD). A beffer knowledge of AFLD will contribute to the prevention and therapy of ALD. It has been found that the occurrence and development of AFLD mainly involve the pathways of cytochrome P450 (CYP2E1),peroxisome proliferator-activated receptor α(PPARα),sterol regulatory element-binding proteins (SREBPs),AMP-activated protein kinase(AMPK),sirtuin 1(SIRT1),adiponectin and insulin.This review focuses on the importance of PPARα,SREBPs and AMPK pathway in alcoholic steatosis.It's reported that alcohol and its metabolite acetaldehyde inhibit PPARα and AMPK,and activate SREBP protein directly or indirectly,leading to liver lipid metabolic disorders,reducing the ability of fatty acid oxidation,causing lipid accumulation, and eventually inducing AFLD. Additionally, this review outlines the prospect of a therapeutics of AFLD targetting PPARα,SREBPs and AMPK.