Thinking about pathogenic mechanism and therapeutic drug for Alzheimer disease / 中国药理学与毒理学杂志

ABSTRACT

Alzheimer disease (AD) is classic neurodegenerative disorders and main cause inducing dementia.The pathogenic mechanistic of AD is not yet well understood,there is no effective therapeutic target and drugs in clinical only ameliorate symptom for short term.So far,there is no success of diseasemodifying drug developed based on main pathogenesis.Facing to all these unsuccessful efforts to develop a disease-modifying treatment for AD,we have to re-examine our philosophy and strategies of drug discovery,and rethink the insights on the molecular mechanisms of AD pathogenesis.This paper reviews current situation of anti-AD drug and give some analysis,thinking and future about direction,progress and challenge of research and development.