Study of axonal guidance growth cue netrin-1 on nano-materials in nerve regeneration / 中国药理学与毒理学杂志

ABSTRACT

Nerve regeneration is a major problem in our society after nerve injury.With the development of nanotechnology,some nano-materials,such as carbon nanotubes and graphene with electrical conductivity,have been used to promote neuronfunctional recovery.Some of the nano-materials,however,are neurotoxic and cause neuronal apoptosis.Nerve injury often leads to the disruption of axons,and broken axons cannot form synapse with target neurons,which affects the repair and regeneration of nerves.Netrin-1 is an important cue in neurogenesis,which can guide the growth and migration of axons and synapse formation during neuronal regeneration.However,some growth factors are used to decorate the surface of nanomateriaes to decrease the toxicity in medicine,but the molecular mechanism by which netrin-1 mediates the toxicity of nanomaterials is not clear yet.In this study,we investigated the nano-materials and the function of netrin-1 in neuronal regeneration in recent years.We have proved that netrin-1 can not only guide the growth and migration of axon and synapse formation,but also promote functional recovery of the neurons which are injured by the toxicity of nanomaterials.Our review will provide a theoretical basis for neuronal regeneration by nanomaterials.