Preparation and Dissolution of Loratadine Nanosuspension Lyophilized Powder / 中国药师
China Pharmacist
; (12): 809-813, 2018.
Article
Dans Zh
| WPRIM
| ID: wpr-705598
Responsable en Bibliothèque :
WPRO
ABSTRACT
Objective:To prepare loratadine nanosuspension lyophilized powder (LTD-NLP) and investigate the dissolution and stability. Methods:LTD-NLP was prepared by an anti-solvent precipitation method; the particle size and morphology were characterized by a laser nanometer particle sizer and a transmission electron microscope (TEM). The optimal lyophilized protective agent was screened out; the dissolution and stability of LTD-NLP were determined by HPLC. Results:The average particle size of LTD-NLP was 175.6 nm with PDI of 0.200, and the zeta potential was -56.3 mV. The shape of LTD-NLP was spherical. The nanosuspension lyophilized with 10% sucrose presented optimal properties. The dissolution of LTD-NLP was greater than raw material, and LTD-NLP had good stability at 4℃. Conclusion:The anti-solvent precipitation method for LTD-NLP is simple,and the product is expected to become a new preparation of loratadine.
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WPRIM
langue:
Zh
Texte intégral:
China Pharmacist
Année:
2018
Type:
Article