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Preparation and Formula Optimization of Diphenidol Hydrochloride Push-pull Osmotic Pump Tablets / 中国药师
China Pharmacist ; (12): 1750-1755, 2018.
Article Dans Chinois | WPRIM | ID: wpr-705697
ABSTRACT

Objective:

To prepare diphenidol hydrochloride push-pull osmotic pump tablets and in-vestigate the influence of differ-ent factors on in-vitro drug release.

Methods:

The cumulative release of different formulas was detected. Using the cumulative release and similarity factor f2as the evaluation criterion, single factor experiment was applied to screen the core formula and coating process.

Results:

The drug release behavior was affected by the content of PEO in the drug containing layer, the content of NaCl and the weight gain of the coating layer. After the formula was optimized, the NaCl content in the drug containing layer was 10mg, the PEO-N10 con-tent was 15mg. In the push layer, the content of PEO-WSR303 was 60 mg, that of NaCl was 20 mg. The optimized coating liquid for-mula contained 1. 25 g·L-1PEG4000 and the coating weight gain was 7% of the core. The optimized formula fitted a zero-order equa-tion within 2-12h with the drug release equation of Q=6. 308t-2. 5037(r=0. 995 8).

Conclusion:

The preparation technology of di-phenidol hydrochloride push-pull osmotic pump tablets is stable, and the in-vitro drug release fits zero-order model.

Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Type d'étude: Étude pronostique langue: Chinois Texte intégral: China Pharmacist Année: 2018 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Type d'étude: Étude pronostique langue: Chinois Texte intégral: China Pharmacist Année: 2018 Type: Article