Value of red blood cell distribution width (RDW) and mean platelet volume (MPV) on emergency department admission in patients with venous thrombosis / 中国医师杂志

ABSTRACT

Objective Mean platelet volume (MPV) and Red Blood Cell Distribution Width (RDW) have been demonstrated to be associated with deep vein thrombosis (DVT).However,their role in the prediction of pulmonary embolism (PE),which is a major complication of DVT,are still unclear.Therefore,we investigated the association of MPV and RDW values with acute PE in patients with DVT.Methods A case-control study was conducted in patients hospitalized in emergency department of Beijing Friendship Hospital from November 2006 to June 2016.The study included three groupspatients with DVT and PE (PE group,n =96),patients with DVT without PE (non PE group,n =95),and control group (No DVT,No PE,n =96).Results (1) MPV was significantly higher in all DVT patients than that in control group (9.8 ±0.5 vs7.8 ±0.6,P ＜0.05;8.6±0.6 vs7.8 ± 0.6,P＜0.05) and MPV was significantly higher in DVT patients with PE than that in DVT patients without PE [(9.8 ± 0.5) fL,(8.6 ± 0.6) fL] (P ＜ 0.05).(2) The percentage of patients with RDW ＞ 14.5％ was significantly higher in PE group and non PE group than that in control group (52.1％ vs 20.8％),and (45.3 ％ vs 20.8％) (P ＜ 0.05).(3) In logistic analysis,MPV is an independent risk factor for PE patients (OR22.18,95％ CI9.36-53.16,P ＜0.01),the area under receiver operating characteristic (ROC) curve is 0.91,and the best critical value is 9.15 fL.The incidence of PE in patients with MPV ＞ 9.15 fL and MVP ＜ 9.15 fL was 75.6％ vs 15％ respectively,with statistically significance (P ＜ 0.05).Conclusions Combining use of RDW and MPV may be used as an early assessment of venous thromboembolism.MPV ＞ 9.15 fL suggests that patients may have PE.