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Correlations of bcl-2 expression with clinicopathological features in breast cancer
Yonsei Medical Journal ; : 206-211, 1997.
Article Dans Anglais | WPRIM | ID: wpr-70663
ABSTRACT
To evaluate the prognostic significance of bcl-2, we investigated the correlation of bcl-2 expression with the established indicators of prognosis and tumor behavior in breast cancer. This study included a patient group of 91 histologically diagnosed female breast carcinomas. To determine the bcl-2 immunoreactivity, we used a monoclonal antibody directed against the bcl-2 protein by immunohistochemistry from paraffin-embedded tissue in a series of 91 women with breast cancer. Interpretable DNA histograms were obtained from 84 patients. The median age at diagnosis was 45.5 years and the median follow-up time was 30.5 months. Forty-eight (52.7%) cancers showed the bcl-2 immunoreactivity in the cytoplasm. The nonneoplastic portion of ductal epithelial cells and normal lymphocytes were usually stained with bcl-2 antibody. Estrogen receptors (ER)(p 0.05) and DNA ploidy (p > 0.05) were not related with it. The bcl-2 positive patients showed longer survival (p 0.05), nuclear grade (p > 0.05), ER status (p > 0.1) and PR status(p > 0.1) were not reliable indicators for overall survival except histologic grade (p < 0.05). Our results suggest that bcl-2 expression may be related to hormonal regulation and tumor differentiation in breast carcinoma. Larger patient study groups with a longer follow-up period will be helpful to clarify the prognostic significance of bcl-2.
Sujets)

Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Tumeurs du sein / Épithélioma in situ / Récepteurs à la progestérone / Récepteurs des oestrogènes / Carcinome canalaire du sein / Protéines proto-oncogènes c-bcl-2 / Adulte d&apos;âge moyen Limites du sujet: Femelle / Humains langue: Anglais Texte intégral: Yonsei Medical Journal Année: 1997 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Tumeurs du sein / Épithélioma in situ / Récepteurs à la progestérone / Récepteurs des oestrogènes / Carcinome canalaire du sein / Protéines proto-oncogènes c-bcl-2 / Adulte d&apos;âge moyen Limites du sujet: Femelle / Humains langue: Anglais Texte intégral: Yonsei Medical Journal Année: 1997 Type: Article