The role and clinical significance of migration and invasion inhibitory protein in the de-velopment and progression of tumors / 中国肿瘤临床

ABSTRACT

Migration and invasion inhibitory protein(MIIP)inhibits cell proliferation,migration,and invasion,impeding tumorigenesis and tumor progression,by interacting with insulin-like growth factor binding protein 2(IGFBP2),histone deacetylase 6(HDAC6),p21 activated kinase 1(PAK1),epidermal growth factor receptor(EGFR),cell division cycle 20(CDC20),and topoisomerase.Recent studies revealed potential roles of MIIP in viral infection and cellular immunity.MIIP has become a research hotspot owing to its involvement in multiple signaling pathways and as a potential therapeutic target for tumors.This review summarizes the characteristics,functions, clinical significance,and possible pathogenic mechanisms of MIIP in multiple carcinomas.