The effects of Xuebijing injection combined with probiotics on the inflammatory response and microcirculation of patients with severe acute pancreatitis / 中国中西医结合急救杂志

ABSTRACT

Objective To investigate the effects of Xuebijing combined with probiotics on levels of inflammatory indexes of procalcitonin (PCT), C-reactive protein (CRP) and microcirculation index D-Dimer in patients with severe acute pancreatitis (SAP). Methods Ninety-two SAP patients admitted to the Affiliated Wujiang Hospital of Nantong University from June 2014 to July 2017 were enrolled, according to the difference in treatment, they were divided into three groups Xuebijing group (n = 31) using 50 mL Xuebijing injection added into 100 mL 0.9% normal saline, intravenously dripped, each time lasting for 30-40 minutes, twice a day; probiotics group (n = 30) applying lactobacillus complex capsules (each capsule weight 0.33 g), 2 capsules once, 3 times a day; Xuebijing combined with probiotics group (n = 31) using the same as above two methods in combination. The routine therapies were given to the patients in the three groups, including anti-acid agents, anti-infection, anti-secretion of pancreas, fluid resuscitation, etc. The venous blood was collected before and after treatment for 5 days and 7 days, the serum PCT, CRP and plasma D-Dimer were detected and the differences in the above indexes among the three groups were compared. Results The serum PCT, CRP and plasma D-Dimer levels were significantly reduced in the three groups after treatment, and with the prolongation of therapeutic time, the reduction in the above index levels was more obvious, the amplitudes of descent in levels of indicators were mostly pronounced in Xuebijing combined with probiotics group on the 7th day of treatment, being significantly greater than those of single Xuebijing group or single probiotics group [PCT (μg/L) 1.21±1.05 vs. 2.37±0.84, 2.43±0.69, CRP (mg/L) 12.57±1.39 vs. 25.24±3.06, 27.32±2.74, D-Dimer (mg/L) 0.61±0.17 vs. 1.02±0.34, 0.94±0.39], however , the levels of PCT, CRP and D-Dimer were of no significant differences between Xuebijing group and probiotics group (all P > 0.05). Conclusions The Xuebijing injection combined with probiotics for treatment of patients with SAP can significantly reduce the levels of PCT, CRP and D-Dimer, ameliorate the inflammatory response, and the therapeutic effect was more evident compared with Xuebijing or probiotics treatment alone. Moreover, this combination therapy can provide early protection for SAP patients.