Early progression of mild ischemic stroke in the elderly / 中华老年心脑血管病杂志

ABSTRACT

Objective To study the risk factors for early neurological deterioration (END) in elderly mild ischemic stroke (MIS) patients.Methods Two hundred MIS patients with their national institute of health stroke scale (NIHSS) score≤3 admitted to the Beijing Zhongguancun Hospital from June 2013 to July 2017 were divided into progressive ischemic stroke group (n=52) and nonprogressive ischemic stroke group (n =148).Their past medical history,clinical symptoms,laboratory testing parameters,and imaging data were compared and analyzed.Results The incidence of diabetes mellitus and ischemic stroke,abnormal circadian rhythm of blood pressure,NIHSS score,serum hs-CRP level,incidence of blood vessel stenosis or occlusion,multiple lesions and watershed cerebral infarction were significantly higher in progressive ischemic stroke group than in non-progressive ischemic stroke group (P ＜ 0.05,P ＜ 0.01).Multivariate logistic regression analysis showed that hs-CRP,abnormal circadian rhythm of blood pressure,blood vessel stenosis or occlusion,multiple lesions,and watershed cerebral infarction were the independent risk factors for END in elderly MIS patients (OR=3.113,95％CI1.483-6.532,P=0.003;OR=2.724,95％CI1.291-5.749,P=0.009;OR=3.499,95％CI1.557-7.860,P=0.002;OR =2.794,95％CI1.359-5.744,P=0.005;OR=3.843,95％CI1.752-8.426,P=0.001).Conclusion hs-CRP,abnormal circadian rhythm of blood pressure,blood vessel stenosis or occlusion,multiple lesions and watershed cerebral infarction are the independent risk factors for END in elderly MIS patients.