Relationship of pulse pressure index with intracranial and extracranial atherosclerosis / 中华老年心脑血管病杂志

ABSTRACT

Objective To study the relationship of pulse pressure index (PPI) with intracranial and extracranial arteriosclerosis.Methods Two hundred and fifty-five patients with cerebrovascular disease,peripheral vertigo and headache admitted to our hospital were divided into normal control group (n=99),plaque group (n=53),mild stenosis group (n=53) with a stenosis rate of ＜30％,moderate stenosis group (n=29) with a stenosis rate of 30％-69％,and severe stenosis group (n=21) with a stenosis rate of 70％-99％ according to their head and neck CT vascular imaging.The patients were further divided into intracranial stenosis group (n=68) and extracranial stenosis group (n =35).Their general condition,laboratory blood test parameters,ambulatory blood pressure (ABP) and mean PPI were recorded.Results The PPI was significantly higher in mild,moderate and severe stenosis groups than in normal control group (0.41 ±0.08,0.41 ±0.05 vs 0.38±0.06,P＜0.01;0.43±0.05 vs 0.38±0.06,P＜0.05).However,no significant difference was found in PPI between intracranial and extracranial stenosis groups (0.41 ±0.06 vs 0.40±0.05,P＞0.05).Correlation analysis showed that intracranial arteriosclerosis was positively related with PPI,hypertension and age (P＜0.01),but not related with gender,diabetes,TC,TG and LDL-C (P＞0.05).Conclusion PPI is related with intracranial arterosclerosis.