Relationship between serum small dense LDL-C level and coronary heart disease / 中华老年心脑血管病杂志

ABSTRACT

Objective To study the relationship between sdLDL-C level and CHD.Methods Two hundred and thirty-one CHD patients were divided into carotid stenosis group (n=119) and carotid stenosis-free group (n=112).The relationship between serum sdLDL-C level and risk factors for CHD were analyzed by logistic stepwise regression analysis.Results The serum sdLDL-C level was significantly higher in carotid stenosis group than in carotid stenosis-free group (P＜0.05).The elevated rate of serum sdLDL-C level was significantly higher in carotid stenosis group than in carotid stenosis-free group when 1.39 mmol/L was set as its upper limit reference cutoff value (36.3％ vs 17.0％,P＜0.05).The serum levels of TC,LDL-C,apoB,D-dimer and Fib were significantly higher while those of HDL-C were significantly lower in carotid stenosis group than in carotid stenosis-free grou (P＜0.05).The serum levels of sdLDL-C were positively related with those of TC,LDL-C,apoB,D-dimer,Fib and negatively related with those of HDL-C (P＜0.01).Logistic stepwise regression analysis showed that TC,LDL-C,apoB,D-dimer,Fib and sdLDL-C were the independent risk factors for CHD (P＜0.05).Conclusion Serum sdLDL-C level is significantly higher in CHD patients and is thus an important risk factor for CHD.