Study on the correlation between normal serum TSH level and components of metabolic syndrome in Guiyang urban residents aged 40-80 years / 中华内分泌代谢杂志

ABSTRACT

A total of 10140 adult residents aged 40-80 years living for more than five years in Yunyan district of Guiyang were recruited by cluster sampling method from May to October, 2011. The epidemiological questionnaire investigations were performed in all subjects and basic information was collected. Body mass index (BMI), waist circumference, blood pressure, blood glucose, blood lipids, serum insulin, and TSH levels were measured. The results showed that the prevalence of metabolic syndrome ( MS) was 40. 3％ in 7743 subjects with normal thyroid function, which was 27. 4％ for men and 45. 6％ for women. The TSH level in MS group was significantly higher than that in non-MS group [(2. 63 ± 1. 01 vs 2. 53 ± 1. 04) mU/ L, P < 0. 01]. Significant differences in BMI, triglycerides(TG), and high density lipoprotein cholesterol(HDL-C) were found in groups with different TSH levels(P<0. 05). The normal TSH level was positively related to TG, fasting insulin,and the prevalence of MS after adjusting for age, BMI, and homeostasis model assessment for insulin resistance ( P < 0. 05). Logistic regression showed that the TSH was an influencing factor for MS(OR=1. 056, 95％ CI 1. 004-1. 111).