Associations between blood glucose level and cardiovascular disease risk in elderly people aged 40 and older in Guiyang City / 中华内分泌代谢杂志

ABSTRACT

Objective To investigate the association between blood glucose level and cardiovascular disease ( CVD) risk in elderly people aged 40 and older in Guiyang City. Methods Population-based cross-sectional studies on diabetes were performed in 10140 adults, aged 40-78 years, living in the Yunyan Community in Guiyang City, during May, 2011 to August, 2011. The fasting venous blood samples were drawn for the measurements of serum creatinine(Cr), fasting plasma glucose(FPG), OGTT 2hPG, fasting triglyceride(TG), total cholesterol(TC), high-density lipoprotein-cholesterol ( HDL-C ) , low-density lipoprotein-cholesterol ( LDL-C ) , and fasting plasma insulin. The diabetes status and the classification system for diabetes in our study were categorized according to the Diabetes Diagnostic Standard which was issued by WHO in 1999. An estimated 10-year Framingham risk for coronary heart disease was calculated. Results Compared with those in normal glucose regulation( NGR) group, the subjects in abnormal glucose metabolism were associated with higher prevalence of various cardiovascular risk factors, including age, body mass index, blood pressure, HbA1C , HOMA-IR, total cholesterol, triglycerides, waist circumference, waist-hip ratio, and creatinine, as well as 10-year Framingham risks for coronary heart disease. The difference was statistically significant ( all P<0. 05 ) . Men were more likely to have cardiovascular risk than women. Women developing the disease only begins to increase after the age of 59. The difference was statistically significant(P<0.05). Compared with the subjects in NGR group, the 10-year Framingham risk for coronary heart disease in impaired fasting glucose ( IFG ) , impaired glucose tolerance ( IGT ) , and diabetes mellitus ( DM ) groups shown 10％of increase were 1.13( OR=1.13, 95％CI 0.81-1.58, P>0.05) , 1.18( OR=1.18, 95％CI 0.95-1.45, P>0.05), and 1.44(OR=1.44, 95％CI 1.10-1.88, P<0.05), respectively, after adjusting for various influencing factors. Conclusion Diabetic patients and pre-diabetic individuals were independently associated with the increased 10-year risks for CVD.