The gamma-aminobutyric acid mechanism of Parkinson's central pain / 中华神经科杂志

ABSTRACT

Pain is a common non-motor symptom in Parkinson's disease (PD) patients, incidence of which is high. PD patients with pain are not only prone to anxiety, depression, sleep disorders and other non-motor symptoms, but also accompanied with motor complications, causing the quality of life declined. The gamma-aminobutyric acid (GABA) neurotransmitters participate in the conduction of sensory pathways in the central nervous system. PD patients were also found that GABA regulation of the sensory pathway is impaired, indicating that GABA is also involved in the occurrence of central pain in PD. In this article we aim to elucidate the role of GABA in the central sensory pathway, and the pathological anatomy, animal anatomy, clinical image and clinical application of GABA damage in pain-related sensory pathways in PD.