Research progress of tissue-engineered tracheal re-epithelialization / 中华胸心血管外科杂志

ABSTRACT

Artificial tracheal grafts are required when repairing extensive tracheal defects that exceed 50％ of total length in adults and 30％ in infants.Alternative options for trachea replacement now are being developed,including autografts,allografts,and prosthetics,or a combination of these,but they have limitations including inflammation,infection.With the advancements made in tissue engineering (TE) in recent years,researchers are focusing their attention on using a tracheal scaffold made from a synthetic polymer or a cadaveric allotransplant.Considering the critical role of epithelium in the trachea,the repithelialization of tracheal grafts has gradually become the focus of tissue engineering tracheal reconstruction.This article will make a summary of the researches on the correlation of tissue-engineered tracheal re-epithelialization.