Expressions of bcl-2-associated athanogene 1 and epithelial growth factor receptor gene in triple negative breast cancer / 肿瘤研究与临床

ABSTRACT

Objective To investigate mRNA expressions of bcl-2-associated athanogene1 (BAG-1), epithelial growth factor receptor(EGFR)in triple negative breast cancer(TNBC). Methods Polymerase chain reaction (PCR) method was used to detect mRNA expression levels of BAG-1 and EGFR in 51 TNBC cases combined with adjacent tissues in Taihe Hospital of Shiyan City from October 2013 to August 2014, and the relationship between gene expression and the clinicopathologic parameters of TNBC patients was analyzed. Results The relative expressions of BAG-1 mRNA and EGFR mRNA were 0.57±0.25,0.61±0.21 respectively in TNBC. The expression level of mRNA in breast cancer (0.19±0.12, t = 5.12) was higher than that in adjacent tissues (0.21±0.11, t = 7.17), and there was no significant difference (P< 0.001). The difference of expressions of BAG-1 mRNA and EGFR mRNA in TNBC patients with different clinical stage or lymph node metastasis were statistically significant (all P< 0.05), but there was no significant difference in mRNA expression level of the patients with different tumor diameter or age (all P > 0.05). Conclusion BAG-1 mRNA, EGFR mRNA are highly expressed in TNBC, which may be related with the poor prognosis and may be a molecular index for predicting the prognosis of TNBC patients.