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Diagnostic Performance of %-2proPSA and Prostate Health Index for Prostate Cancer: Prospective, Multi-institutional Study
Journal of Korean Medical Science ; : e94-2018.
Article Dans Anglais | WPRIM | ID: wpr-713491
ABSTRACT

BACKGROUND:

We evaluated the clinical performance of [-2]proPSA (p2PSA) and its derivatives in predicting the presence and aggressiveness of prostate cancer (PCa) in Korean men.

METHODS:

A total of 246 men with total prostate-specific antigen (tPSA) ≥ 3.5 ng/mL who underwent their first prostate biopsy were included in this prospective, multicenter, observational study. Diagnostic accuracy of tPSA, free-to-total PSA ratio (%fPSA), p2PSA, %p2PSA, and the Beckman Coulter prostate health index (PHI) was assessed by receiver operating characteristic curve analyses and logistic regression analyses.

RESULTS:

Overall, PCa was detected in 125 (50.8%) subjects. In men with tPSA 3.5–10 ng/mL, the detection rate of PCa was 39.4% (61/155). In this group, PHI and %p2PSA were the most accurate predictors of PCa and significantly outperformed tPSA and %fPSA; area under the curve for tPSA, %fPSA, %p2PSA, and PHI was 0.56, 0.69, 0.74, and 0.76, respectively. PHI was also the strongest predictor of PCa with Gleason score ≥ 7.

CONCLUSION:

This study demonstrates the superior clinical performance of %p2PSA and PHI in predicting the presence and aggressiveness of PCa in Korean men. The %p2PSA and PHI appear to improve detection of PCa and provide prognostic information.
Sujets)

Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Prostate / Tumeurs de la prostate / Biopsie / Anaphylaxie cutanée passive / Marqueurs biologiques / Modèles logistiques / Études prospectives / Courbe ROC / Antigène spécifique de la prostate / Diagnostic précoce Type d'étude: Essai clinique contrôlé / Etude diagnostique / Étude observationnelle / Étude pronostique / Facteurs de risque / Étude de dépistage Limites du sujet: Humains / Mâle langue: Anglais Texte intégral: Journal of Korean Medical Science Année: 2018 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Prostate / Tumeurs de la prostate / Biopsie / Anaphylaxie cutanée passive / Marqueurs biologiques / Modèles logistiques / Études prospectives / Courbe ROC / Antigène spécifique de la prostate / Diagnostic précoce Type d'étude: Essai clinique contrôlé / Etude diagnostique / Étude observationnelle / Étude pronostique / Facteurs de risque / Étude de dépistage Limites du sujet: Humains / Mâle langue: Anglais Texte intégral: Journal of Korean Medical Science Année: 2018 Type: Article