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Alginate-Catechol Cross-Linking Interferes with Insulin Secretion Capacity in Isolated Murine Islet Cells
Diabetes & Metabolism Journal ; : 164-168, 2018.
Article Dans Anglais | WPRIM | ID: wpr-714101
ABSTRACT
Over the past three decades, human pancreatic islet isolation and transplantation techniques have developed as a routine clinical procedure for selected patients with type 1 diabetes mellitus. However, due to the donor shortage and required chronic systemic immunosuppression, the widespread application of islet transplantation is limited. To overcome these limitations, providing a physical barrier to transplanted islet cells with encapsulating biomaterial has emerged as a promising approach to enhance engraftment and promote islet survival post-transplantation. Alginate has been considered to be a reliable biomaterial, as it enhances islet survival and does not hamper hormone secretion. Alginate-catechol (Al-CA) hydrogel was reported to provide high mechanical strength and chemical stability without deformation over a wide range of pH values. In this study, we, demonstrated, for the first time in the literature, that encapsulation of murine pancreatic islet cells with Al-CA hydrogel does not induce cytotoxicity ex vivo for an extended period; however, it does markedly abate glucose-stimulated insulin secretion. Catechol should not be considered as a constituent for alginate gelation for encapsulating islet cells in the application of islet transplantation.
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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Accessibilité architecturale / Donneurs de tissus / Téméfos / Transplantation d'ilots de Langerhans / Ilots pancréatiques / Immunosuppression thérapeutique / Hydrogels / Diabète de type 1 / Concentration en ions d'hydrogène / Insuline Limites du sujet: Humains langue: Anglais Texte intégral: Diabetes & Metabolism Journal Année: 2018 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Accessibilité architecturale / Donneurs de tissus / Téméfos / Transplantation d'ilots de Langerhans / Ilots pancréatiques / Immunosuppression thérapeutique / Hydrogels / Diabète de type 1 / Concentration en ions d'hydrogène / Insuline Limites du sujet: Humains langue: Anglais Texte intégral: Diabetes & Metabolism Journal Année: 2018 Type: Article