Liver Fluke-Associated Biliary Tract Cancer
Gut and Liver
;
: 236-245, 2018.
Article
Dans Anglais
| WPRIM
| ID: wpr-714618
ABSTRACT
Cholangiocarcinoma (CCA) is an aggressive cancer arising from epithelial cells of the bile duct. Most patients with CCA have an unresectable tumor at the time of diagnosis. In Western countries, the risk of CCA increases in patients with primary sclerosing cholangitis, whereas liver fluke infection appears to be the major risk factor for CCA in Asian countries. A diagnosis of liver fluke infection often relies on stool samples, including microscopic examination, polymerase chain reaction-based assays, and fluke antigen detection. Tests of serum, saliva and urine samples are also potentially diagnostic. The presence of liver fluke along with exogenous carcinogens magnifies the risk of CCA in people living in endemic areas. The “liver fluke-cholangiocarcinoma” carcinogenesis pathways consist of mechanical damage to the bile duct epithelium, immunopathologic and cellular reactions to the liver fluke's antigens and excretory/secretory products, liver fluke-induced changes in the biliary tract microbiome and the effects of repeated treatment for liver fluke. A vaccine and novel biomarkers are needed for the primary and secondary prevention of CCA in endemic areas. Importantly, climate change exerts an effect on vector-borne parasitic diseases, and awareness of liver fluke should be enhanced in potentially migrated habitat areas.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Opisthorchiase
/
Maladies parasitaires
/
Salive
/
Trematoda
/
Changement climatique
/
Conduits biliaires
/
Voies biliaires
/
Tumeurs des voies biliaires
/
Cancérogènes
/
Marqueurs biologiques
Type d'étude:
Etude diagnostique
/
Etude d'étiologie
/
Facteurs de risque
Limites du sujet:
Humains
langue:
Anglais
Texte intégral:
Gut and Liver
Année:
2018
Type:
Article
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