Reference intervals of thyroid hormones during pregnancy in Korea, an iodine-replete area
The Korean Journal of Internal Medicine
;
: 552-560, 2018.
Article
Dans Anglais
| WPRIM
| ID: wpr-714637
ABSTRACT
BACKGROUND/AIMS:
Maternal thyroid dysfunction has been associated with adverse pregnancy outcomes. The purpose of our study was to establish trimester-specific reference intervals for thyroid hormones in pregnant women in Korea, where iodine intake is more than adequate and to examine pregnancy and perinatal outcomes in their offspring.METHODS:
Among 459 healthy pregnant women who were screened, we enrolled 417 subjects who had negative results for thyroid autoantibodies. Serum thyroid stimulating hormone (TSH) and free thyroxine were measured using an immunoradiometric assay. Urine iodine concentration was measured using inductively coupled plasma-mass spectrometry in 275 women. Reference ranges of thyroid hormones were determined according to the guidelines of the National Academy of Clinical Biochemistry. Pregnancy and perinatal outcomes were compared according to maternal thyroid function.RESULTS:
The reference ranges of serum TSH were 0.03 to 4.24 mIU/L in the first trimester, 0.13 to 4.84 mIU/L in the second trimester, and 0.30 to 5.57 mIU/L in the third trimester. Pregnancy and perinatal outcomes did not vary in mothers with subtle changes in thyroid function.CONCLUSIONS:
Trimester-specific thyroid hormone reference intervals in Korean pregnant women differ from those of other countries with different iodine nutrition status and ethnicity. The establishment of population-based, reliable trimester-specific reference intervals is critical for the interpretation of thyroid function in pregnant women to avoid unnecessary tests and treatments.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Deuxième trimestre de grossesse
/
Troisième trimestre de grossesse
/
Premier trimestre de grossesse
/
Valeurs de référence
/
Autoanticorps
/
Analyse spectrale
/
Glande thyroide
/
Hormones thyroïdiennes
/
Thyroxine
/
Biochimie
Type d'étude:
Guide de pratique
Limites du sujet:
Femelle
/
Humains
/
Grossesse
Pays comme sujet:
Asie
langue:
Anglais
Texte intégral:
The Korean Journal of Internal Medicine
Année:
2018
Type:
Article
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